Bis(trimethylsilyl)trifluoroacetamide: A Highly Efficient Derivatizing Agent for GC Analysis
Bis(trimethylsilyl)trifluoroacetamide: A Highly Efficient Derivatizing Agent for GC Analysis
Bis(trimethylsilyl)trifluoroacetamide, commonly known as BSTFA, is a widely used derivatizing agent in gas chromatography (GC) analysis. It is a colorless, clear liquid with a strong fruity odor and a molecular formula of C8H18F3NOSi2. INNO Specialty Chemicals is a leading manufacturer and supplier of BSTFA from China, providing high-quality products to customers worldwide.
BSTFA is a versatile compound that can be used for various chemical reactions, such as silylation, esterification, and acylation. It is particularly useful in GC analysis, where it is used to convert polar and/or labile compounds into volatile and thermally stable derivatives that can be easily separated and analyzed by GC. BSTFA reacts with hydroxyl (OH), carboxyl (COOH), and amino (NH2) groups present in the analytes, forming trimethylsilyl (TMS) derivatives that are stable and volatile.
BSTFA has several advantages over other derivatizing agents used in GC analysis, such as trimethylchlorosilane (TMCS) and N,O-bis(trimethylsilyl)acetamide (BSA). Firstly, BSTFA is more efficient in silylating polar compounds, such as carbohydrates, amino acids, and steroids, due to the presence of trifluoroacetyl (TFA) group in its structure. TFA group enhances the reactivity of BSTFA towards polar analytes and improves the stability of TMS derivatives formed.
Secondly, BSTFA is less prone to hydrolysis than TMCS and BSA, which makes it more suitable for analyzing labile compounds, such as alcohols, phenols, and carboxylic acids. BSTFA can also be used for silylating non-labile compounds, such as hydrocarbons, which makes it a more versatile derivatizing agent than TMCS and BSA.
Thirdly, BSTFA is easier to handle than TMCS and BSA, as it is a liquid at room temperature and does not require any special handling or storage conditions. TMCS and BSA are both solids that require careful handling and storage to prevent moisture absorption and degradation.
BSTFA is commercially available in various forms, such as pure liquid, derivatization kits, and pre-column derivatization cartridges. INNO Specialty Chemicals offers high-quality BSTFA products that are suitable for different GC applications, such as environmental analysis, food analysis, and pharmaceutical analysis.
In conclusion, BSTFA is a highly efficient derivatizing agent for GC analysis that offers several advantages over other silylating agents. It is versatile, stable, and easy to handle, making it a preferred choice for many GC analysts. INNO Specialty Chemicals is a reliable supplier of BSTFA from China, providing high-quality products and excellent customer service to customers worldwide.
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