Introducing 2-Chlorobenzoyl Chloride

CAS Number: 609-65-4
Synonyms: o-Chlorobenzoyl chloride; 2-chlorobenzoyl chloride; benzoyl chloride, 2-chloro-; o-chlorobenzoylchloride

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Overview

2-Chlorobenzoyl chloride is a versatile chemical compound widely utilized in the fields of pharmaceuticals, agrochemicals, and organic synthesis. Its unique structure featuring both chlorine and benzoyl functional groups renders it a valuable intermediary in the production of a wide array of chemical products.

Chemical Properties

- Molecular Formula: C7H5ClO
- Molecular Weight: 156.57 g/mol
- Appearance: Clear to pale yellow liquid
- Boiling Point: Approximately 225°C
- Solubility: Soluble in organic solvents such as dichloromethane and ether

2-Chlorobenzoyl chloride exhibits reactivity characteristic of acyl chlorides and can readily participate in nucleophilic acyl substitution reactions.

Applications

Pharmaceutical Synthesis
2-Chlorobenzoyl chloride serves as a key intermediate in the synthesis of various pharmaceutical compounds. It is effective in the chlorination of aromatic compounds and facilitates the formation of diverse drug molecules.

Agrochemicals
In agrochemical formulations, 2-chlorobenzoyl chloride is utilized for synthesizing herbicides, fungicides, and insecticides. Its ability to introduce a chlorinated benzoyl group enhances the efficacy of agrochemical agents.

Organic Synthesis
It is a critical reagent in organic synthesis, often employed in preparing other chlorobenzoyl derivatives and special fine chemicals. The compound's reactive nature allows it to be involved in various coupling reactions, contributing to the complexity of organic molecules.

Quality Standards

At Ningbo Inno Pharmchem, we uphold stringent quality standards to ensure that our 2-Chlorobenzoyl chloride meets the requirements of various industrial applications. Our product undergoes rigorous testing for purity, stability, and reactivity, allowing us to offer high-quality intermediates essential for your research and production needs.

Synthesis and Preparation

The synthesis of 2-chlorobenzoyl chloride is typically achieved through the reaction of 2-chlorobenzoic acid with thionyl chloride or oxalyl chloride. This process effectively converts the carboxylic acid into its corresponding acyl chloride, facilitating subsequent reactions in various applications.

Preparation Method
1. Materials Needed:
- 2-Chlorobenzoic acid
- Thionyl chloride (or oxalyl chloride)

2. Procedure:
- Gradually add the 2-chlorobenzoic acid to thionyl chloride in a controlled environment, typically using a round-bottom flask equipped with a reflux condenser.
- Heat the mixture gently until the reaction is complete, removing excess thionyl chloride by distillation.
- Purify the resulting 2-Chlorobenzoyl chloride via distillation or chromatography, as required.

3. Yield: The yield can vary based on the conditions used, but high purity can typically be achieved with proper technique.

Conclusion

2-Chlorobenzoyl chloride is a vital chemical with significant importance across various industrial sectors. With its diverse applications and the ability to act as a building block in more complex molecules, it continues to play a crucial role in advancing multiple fields. Ningbo Inno Pharmchem is proud to supply this essential compound, ensuring the highest quality and reliability for all your chemical needs.

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